Anti-redness facial serum for sensitive, reactive, or irritated complexions  / 1 oz

twelveLab B12 Calm Serum, a redness-soothing serum for reactive skin, is an obvious can’t-miss from this lineup of products that are all winners for sensitive complexions.

Founder Pedro Catalá has done countless consultations with our customers as well as his own in Spain, and he noted, “One concern that comes up repeatedly is how to reduce persistent redness, soothe reactive skin, and restore calm to complexions affected by sensitivity, inflammation, or environmental aggressors. B12 Calm Serum has been carefully developed to meet these needs, offering a fast-absorbing, non-irritating formula that comforts, cools and protects from the first application…it is my tribute to those reactive skin types that can’t tolerate anything.”

It's a beautiful tribute indeed. The silky, fragrance-free formula, audaciously bold in color — it’s red! — feels super light and absorbs quickly, making it an excellent first layer underneath any additional serums or moisturizers you might want to pile on. Key ingredients include Vitamin B12, renowned for its calming, reparative properties, and a blend of botanicals like marine-derived Alteromonas Ferment Extract to help calm flare-ups, reduce visible redness, and strengthen the skin’s protective barrier.

In TWELVE’s 2-week user trial, 96% of the 23 participants found that their skin felt calmer, and 73% reported a visible reduction in redness. Rosacea-prone complexions, take note: trial participants with rosacea noticed a significant decrease in flushing and redness. Pedro notes, “With regular use, skin will appear more balanced, even-toned, and resilient.” 

Bonus: it’s not just for delicate flowers, either. B12 Calm will also come in handy for skin irritated by sun exposure and those recovering from surgery or cosmetic procedures. If you have days in the sun or a cosmetic procedure in your calendar this season, pick up a bottle ahead of time.