Rejuvenating, elasticity-boosting intensive face treatment with salmon PDRN / 4 x .17 oz ampoules 

VENN’s Rejuvenative PDRN-NE Ampoule is a high-performance skin-conditioning face serum that has taken the beauty editor world by storm—including those with the most exacting standards.

Topical PDRN is widely viewed by dermatologists as an effective maintenance strategy to enhance radiance, support barrier strength, and improve overall skin quality: a treatment that’s adjacent to, but not a replacement for, the injectable treatments that have gone viral.

VENN’s product takes topical PDRN to the next level, with highly purified, salmon DNA-derived polydeoxyribonucleotide at a clinically optimized 1% concentration that’s delivered through a proprietary nano-emulsion delivery system to visibly lift, firm, smooth, and refine the complexion. It’s packaged as a four-week program (each 5ml vial lasts a week) to help improve the appearance of skin elasticity, firmness, tone, and smoothness, leaving the complexion looking more refined and revitalized. It absorbs softly into the skin while providing a comforting veil of moisture—ideal for dry, mature, or fatigued skin that needs visible revitalization and support.

Its delivery system is key: as founder Brian Oh said to Dara, “[PDRN] has become a global phenomenon, and for good reason: it has real, validated, regenerative benefits. It's been used in medical clinics in Korea and across Asia for years. But the challenge with PDRN is that intact sodium DNA doesn't absorb through the skin on its own; the molecular size is simply too large.

“So you see some brands using hydrolyzed sodium DNA, which breaks down the chain so it can absorb. But once you break it down, you've lost the regenerative properties. At best, it functions as a humectant. Other brands use intact sodium DNA at very high percentages, but without a delivery system, it isn't absorbing either.

“That's where our nano-emulsion delivery system comes in. We encapsulate intact salmon DNA in nanoparticles small enough to penetrate the skin. The DNA chain coils and is encapsulated within these nano vehicles. Through testing, we've been able to confirm that the PDRN does absorb, and that absorption translates into the visible, meaningful skin benefits you'd expect.”

VENN’s formula is further elevated with a powerful network of peptides and vegan EGF, 17 amino acids, encapsulated panthenol, a multi-layer hydration system, and barrier-reinforcing ingredients including ectoin, ceramide NP, and glutathione. Together, they help improve the look of firmness, elasticity, tone, and radiance while supporting a smoother, healthier-looking complexion.

If those results sound too nebulous for you, check out the specific things that were measured and/or noticed in both clinical and consumer tests below.

Clinical results (based on a 2-week in-vivo clinical study, 20 subjects):
+ Improved surface and deep skin elasticity
+ Visible lifting of cheeks, chin, nasolabial folds, and mouth corners
+ Reduced appearance of wrinkles
+ Reduced visible redness
+ Diminished superficial dark spots and hyperpigmentation
+ Improved look of deep pigmentation

Consumer perception results (20 subjects, 2 weeks, morning and evening use):
+ 100% agreed skin felt more elastic, lifted, soothed, healthier, and younger
+ 100% agreed skin tone looked improved and more even; pores looked smaller; skin looked brighter
+ 95% agreed wrinkles around the eyes looked reduced

If you're a Sea Serum fan, reach for this one anytime your skin needs an extra healing boost (after a cold, after being too aggressive with your skincare treatments, after stretches of travel or stress), layering it under the Sea Serum.